Comparing PRP, BMAC, and MFAT: Choosing the Right Regenerative Treatment

Regenerative medicine continues to revolutionize how we approach healing, recovery, and long-term tissue health. Among the most talked-about therapies are PRP (Platelet-Rich Plasma), BMAC (Bone Marrow Aspirate Concentrate), and MFAT (Micro-Fragmented Adipose Tissue). Each has unique characteristics, benefits, and ideal use cases — but how do you choose the right one?

In this post, we’ll explore what each treatment is, how it works, and what factors to consider when deciding which might be best for you.

What Are These Treatments?

PRP (Platelet-Rich Plasma)

PRP is created by drawing a small amount of your blood and spinning it in a centrifuge to concentrate the platelets. Platelets contain growth factors that help initiate healing.

• Good for: Tendon injuries (e.g., tennis elbow), mild to moderate osteoarthritis, muscle strains, some ligament injuries
• Benefits: Minimally invasive; lower cost compared to cellular therapies; well-studied with strong safety profile

BMAC (Bone Marrow Aspirate Concentrate)

BMAC is collected from bone marrow (usually the pelvis). It contains stem cells, growth factors, and cytokines important for regeneration.

• Good for: Moderate to severe osteoarthritis, cartilage injuries, bone healing, tendon and ligament support
• Benefits: Higher concentration of regenerative cells than PRP, supports both healing and anti-inflammatory processes
• Considerations: More invasive than PRP, typically higher cost

MFAT (Micro-Fragmented Adipose Tissue)

MFAT is derived from your own fat tissue using gentle processing techniques. It contains a rich mix of growth factors, stromal cells, and supportive tissues.

• Good for: Joint arthritis (especially knees and hips), soft tissue conditions, cartilage support
• Benefits: Abundant source of regenerative cells, often good for larger joints, less invasive than BMAC harvesting
• Considerations: Requires a small fat harvest (liposuction technique), cost varies based on provider

How Do They Compare?

Which One Is Right For You?

There’s no “one size fits all” answer — but here are some general guidelines:

Choose PRP if:

• You have mild to moderate soft tissue problems
• You want a less invasive, lower-cost option
• Your goal is to reduce inflammation and stimulate healing

Choose BMAC if:

• You’re dealing with moderate to severe osteoarthritis or cartilage damage
• You want a higher concentration of regenerative cells
• Prior conservative treatments haven’t helped

Choose MFAT if:

• You have larger joints like knees or hips involved
• You want broad tissue support and cushioning
• You’re comfortable with a small adipose harvest

Important Things to Consider

• Your specific condition and imaging findings
• Physician experience and technique
• Cost and insurance coverage
• Realistic expectations

Regenerative treatments are promising, but outcomes vary by patient and condition. A thorough evaluation by a trained specialist is essential for optimal results.

Bottom Line

PRP, BMAC, and MFAT are all valuable regenerative tools — and the best choice depends on your injury type, severity, and healing goals. Working with an experienced provider will help tailor a plan that fits your needs and maximizes your chance of recovery.